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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/AP 811/5498/1/1毫克

Tocris/AP 811/5498/1/1毫克

价格
￥4700.00
货号：5498/1
浏览量：127
品牌：Tocris
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商品描述
Description:Highaffinity,selectiveNPR3antagoNIST
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highaffinity,selectiveANPclearancereceptor(NPR3)antagonist(Ki=0.45nM).Exhibits>20,000-foldselectivityforNPR3overNPR1.InhibitsANP-stimulatedNa+/K+pumpactivityinrabbitventricularcardiomyocytesinvitro.AlsoblocksproliferationofrodentneonatalcardiomyocytesseenatlowANPconcentrationsinvitro.

TechnicalData

M.Wt915.1
FormulaC46H66N12O8
SequenceRIDR

(Modifications:Arg-1=N2-[4-(2-Naphthoylamino)phenylacetyl],Arg-4=C-terminal(S)-2-methylbutylamide)

StorageStoreat-20°C
CASNumber124833-45-0
PubChemID44301714
InChIKeyUNMJSSQZDQBGDS-OCFLPWLCSA-N
SmilesCC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1=CC=C(NC(=O)C2=CC3=C(C=CC=C3)C=C2)C=C1)[C@@H](C)CC

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight915.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.09mL5.46mL10.93mL
5mM0.22mL1.09mL2.19mL
10mM0.11mL0.55mL1.09mL
50mM0.02mL0.11mL0.22mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet