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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/Zosuquidar trihydrochloride/5456/10/10 mg

Tocris/Zosuquidar trihydrochloride/5456/10/10 mg

价格
￥3700.00
货号：5456/10
浏览量：127
品牌：Tocris
服务
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商品描述
Description:HighaffinityP-gpinhibitor
AlternativeNames:LY335979
ChemicalName:(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanoltrihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityP-glycoprotein(P-gp)inhibitor(Kd=79nM).Restoresdoxorubicin(Cat.No.2252)sensitivityinP-gp-expressingmultidrug(MDR)resistantcancercelllines.Alsopotentiatesantitumorefficacyoftaxol(Cat.No.1097)inaMDRhumannon-smallcelllungcarcinomaxenograftmousemodel.

CompoundLibraries

ZosuquidartrihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt636.99
FormulaC32H31F2N3O2.3HCl
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber167465-36-3
PubChemID153997
InChIKeyZPFVQKPWGDRLHL-ZLYBXYBFSA-N
SmilesF[C@@]2(F)[C@H]1C3=C(C=CC=C3)[C@H](N5CCN(C[C@H](COC6=CC=CC7=C6C=CC=N7)O)CC5)C4=C(C=CC=C4)[C@H]12.Cl.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.8550

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight636.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.57mL7.85mL15.7mL
5mM0.31mL1.57mL3.14mL
10mM0.16mL0.78mL1.57mL
50mM0.03mL0.16mL0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet