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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/盐酸拓扑替康/4562/10/10 mg

Tocris/盐酸拓扑替康/4562/10/10 mg

价格
￥1180.00
货号：4562/10
浏览量：127
品牌：Tocris
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商品描述
Description:DNAtopoisomeraseIinhibitor;Camptothecin(Cat.No.1100)analog
AlternativeNames:SK&F104864-A
ChemicalName:10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DNAtopoisomeraseIinhibitor;inducesrapidapoptoticdeathinhumanB-lineageacutelymphoblasticleukemia(ALL)cells.ImprovessurvivalinthreemousemodelsofpoorprognosisALL;downregulatesB-MybandMycNexpressioninneuroblastomacells.Water-solubleanalogofCamptothecin(Cat.No.1100).Orallybioavailable.

TechnicalData

M.Wt457.91
FormulaC23H23N3O5.HCl
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber119413-54-6
PubChemID60699
InChIKeyDGHHQBMTXTWTJV-BQAIUKQQSA-N
SmilesOC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2)C2=C1CN(C)C.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO45.79100
water45.79100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight457.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.18mL10.92mL21.84mL
5mM0.44mL2.18mL4.37mL
10mM0.22mL1.09mL2.18mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet