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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/CCT 031374氢溴酸盐/4675/10/10毫克

Tocris/CCT 031374氢溴酸盐/4675/10/10毫克

价格
￥3300.00
货号：4675/10
浏览量：127
品牌：Tocris
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商品描述
Description: Inhibits TCF-dependent transcription; lowers β-catenin levels
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide
Purity: ≥98% (HPLC)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.

Compound Libraries

CCT 031374 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 434.33
Formula C23H19N3O.HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1219184-91-4
PubChem ID 18554738
InChI Key MPILENOYNNNGKO-UHFFFAOYSA-N
Smiles O=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 434.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963 PMID: 20610623

Keywords: CCT 031374 hydrobromide, supplier, CCT031374, hydrobromide, TCF, transcription, inhibitors, inhibits, beta-catenin, b-catenin, β-catenin, stabilization, Beta-catenin, Beta-catenin, Tocris Bioscience

我们的目的是通过提供全球范围内性能最高，最具创新性的研究试剂，使新的生命科学发现成为可能。 我们所做的 Tocris Bioscience是高性能生命科学试剂，肽和抗体的领先供应商，其客户几乎遍布全球所有主要的制药公司，大学和研究机构。该公司致力于通过提供最具创新性的高纯度产品来推动生命科学研究。我们的1,800多种试剂目录代表着独特的，新颖的，专有的和许可的研究工具，并且每年发送给全球50,000多名科学家。Tocris产品供科学家在癌症，心血管疾病，疼痛和感染等领域进行非临床研究时使用。