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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/CCMI/3837/50/50 mg

Tocris/CCMI/3837/50/50 mg

价格
￥10700.00
货号：3837/50
浏览量：127
品牌：Tocris
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商品描述
Description: Positive allosteric modulator of α7 nAChR
Alternative Names: XY 4083
Chemical Name: [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Compound Libraries

CCMI is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 388.25
Formula C19H15Cl2N3O2
Storage Store at -20°C
CAS Number 917837-54-8
PubChem ID 67042344
InChI Key VMAKIACTLSBBIY-UHFFFAOYSA-N
Smiles CC1=NOC(=C1)C(=CNC1=CC=C(Cl)C=C1)C(=O)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.83 100
ethanol 3.88 10

Preparing Stock Solutions

The following data is based on the product molecular weight 388.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.88 mL 25.76 mL
5 mM 0.52 mL 2.58 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Gronlien et al (2007) Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715 PMID: 17565004

Hu et al (2009) Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 158 1857 PMID: 20050184

Ng et al (2007) Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc.Natl.Acad.Sci. 104 8059 PMID:

Keywords: CCMI, supplier, Positive, allosteric, modulators, α7, alpha7, a7, nAChR, Nicotinic, Receptors, Acetylcholine, XY4083, XY, 4083, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience

我们的目的是通过提供全球范围内性能最高，最具创新性的研究试剂，使新的生命科学发现成为可能。 我们所做的 Tocris Bioscience是高性能生命科学试剂，肽和抗体的领先供应商，其客户几乎遍布全球所有主要的制药公司，大学和研究机构。该公司致力于通过提供最具创新性的高纯度产品来推动生命科学研究。我们的1,800多种试剂目录代表着独特的，新颖的，专有的和许可的研究工具，并且每年发送给全球50,000多名科学家。Tocris产品供科学家在癌症，心血管疾病，疼痛和感染等领域进行非临床研究时使用。