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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/脑利钠肽（1-32）（人类）/3522/1/1mg

Tocris/脑利钠肽（1-32）（人类）/3522/1/1mg

价格
￥7580.00
货号：3522/1
浏览量：127
品牌：Tocris
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商品描述
Description: Endogenous peptide agonist at ANP receptor A (NPR1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de novo collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vivo.

Technical Data

M. Wt 3464.05
Formula C143H244N50O42S4
Sequence SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

(Modifications: Disulfide bridge between 10 - 26)
Storage Store at -20°C
CAS Number 124584-08-3
PubChem ID 53325981
InChI Key HPNRHPKXQZSDFX-OAQDCNSJSA-N
Smiles [H]N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.10 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3464.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.29 mL 1.44 mL 2.89 mL
5 mM 0.06 mL 0.29 mL 0.58 mL
10 mM 0.03 mL 0.14 mL 0.29 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Tsuruda et al (2002) Brain natriuretic peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Circ.Res. 91 1127 PMID: 12480813

Wellard et al (2006) Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo. Neurosci.Lett. 392 187 PMID: 16278044

Heublein et al (2007) Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various forms of human B-type natriuretic peptide. Hypertension 49 1114 PMID: 17372040

Keywords: Brain natriuretic peptide (1-32) (human), supplier, Endogenous, peptide, agonists, ANP, receptor, A, NRP1, Receptors, Atrial, Natriuretic, Peptide, Natriuretic, Peptide, Receptor, Natriuretic, Peptide, Receptor, Tocris Bioscience

我们的目的是通过提供全球范围内性能最高，最具创新性的研究试剂，使新的生命科学发现成为可能。 我们所做的 Tocris Bioscience是高性能生命科学试剂，肽和抗体的领先供应商，其客户几乎遍布全球所有主要的制药公司，大学和研究机构。该公司致力于通过提供最具创新性的高纯度产品来推动生命科学研究。我们的1,800多种试剂目录代表着独特的，新颖的，专有的和许可的研究工具，并且每年发送给全球50,000多名科学家。Tocris产品供科学家在癌症，心血管疾病，疼痛和感染等领域进行非临床研究时使用。