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Biological Activity
Endogenous peptide produced by the heart; involved in blood pressure regulation. Produces natriuresis, diuresis and vasorelaxation in vivo.
Technical Data
| M. Wt | 3062.43 |
| Formula | C128H205N45O39S2 |
| Sequence |
SLRRSSCFGGRIDRIGAQSGLGCNSFRY (Modifications: Disulfide bridge between 7 - 23) |
| Storage | Desiccate at -20°C |
| CAS Number | 88898-17-3 |
| PubChem ID | 16166338 |
| InChI Key | QGFSVPWZEPKNDV-BRTFOEFASA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3062.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 5 mM | 0.07 mL | 0.33 mL | 0.65 mL |
| 10 mM | 0.03 mL | 0.16 mL | 0.33 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.07 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Atlas et al (1985) Atrial natriuretic factor (auriculin): structure and biological effects. J.Clin.Hypertens. 1 187 PMID: 2941526
de Bold et al (1985) Atrial natriuretic factor: a hormone produced by the heart. Science 230 767 PMID: 2932797
Rubattu and Volpe (2001) The atrial natriuretic peptide: a changing view. J.Hypertens. 19 1923 PMID: 11677356
Keywords: Atrial Natriuretic Factor (1-28) (rat), supplier, Endogenous, peptide, regulating, blood, pressure, ANP, Receptors, Atrial, Natriuretic, Peptide, NPR, Atrial, Natriuretic, Peptide, (1-28), (rat), Natriuretic, Peptide, Receptor, Natriuretic, Peptide, Receptor, Tocris Bioscience
