Ubenimex hydrochloride

B-1075

65391-42-6

(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride

C₁₆H₂₄N₂O₄ • HCl

344.8 Da

White powder

≥98% (HPLC)

Clear to slightly hazy 10mg/ml in water, Up to 20mg/ml in HCI and Up to 5mg/ml in MeOH.

213-215°C

N/A

-20°C, desiccated

Oncological disorders

Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.

N/A

MFCD00058004

X1087674-3

InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1

CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O.Cl

Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.

MSDS Documentation

B-1075, Bestatin HCl, SDS, diamond format.pdf

B-1075, J1212B.pdf

B-1075, J1212A.pdf

B-1075, J1212.pdf