Actinomycin IV; Actinomycin C1; Dactinomycin; Cosmegen; Meractinomycin; NCI C04682; NSC 3053; Oncostatin K; Glycopeptide, 4a

A-1022

50-76-0

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

C₆₂H₈₆N₁₂O₁₆

1255.42 Da

Red to red-orange crystalline powder

≥99%

Clear orange solution at 50 mg/mL DMSO or 10 mg/mL MeOH

255 - 257°C

N/A

4°C, desiccated

Oncological Disorders

For laboratory and research use only. Actinomycin D and its fluorescent derivative, 7-aminoactinomycin D (7-AAD), are used as stains in microscopy and flow cytometry applications. The affinity of these stains/compounds for GC-rich regions of DNA strands makes them excellent markers for DNA. 7-AAD binds to single stranded DNA; therefore it is a useful tool in determining apoptosis and distinguishing between dead cells and live ones.

12.2867.1996

MFCD00005033

X1005390-0

InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1

C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C

AU1575000

UN 3462

II

Warning: Very TOXIC. For research use only. Not for human or drug use. The pharmacological and toxicological properties of this product have not been fully investigated. Use caution when handling. Do not use this compound if you are not fully trained or are unaware of the hazards involved.Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.

Yes

MEMBRANE TRANSPORT, STRUCTURE, FUNCTION, AND BIOGENESIS:Respiratory Syncytial Virus Inhibits Lung Epithelial Na+ Channels by Up-regulating Inducible Nitric-oxide SynthaseWeifeng Song, Gang Liu, Charles A. Bosworth, John R. Walker, George A. Megaw, Ahmed Lazrak, Edward Abraham, Wayne M. Sullender, and Sadis MatalonJ. Biol. Chem., Mar 2009; 284: 7294 - 7306.

http://www.jbc.org/cgi/reprint/284/11/7294

A-1022, Actinomycin D, SDS, diamond format.pdf

A-1022, J1130.pdf

A-1022, H1395.pdf

A-1022, H1254A.pdf