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Tips for International Students and Study Abroad

mayitao /发布时间:1530930564 /浏览量:19

OVERVIEW:

Synonyms	MonoclonalGAPDHSO3antibody,Anti-GAPDHSO3antibody,GAPDHantibody,glyceraldehyde-3-phosphatedehydrogenaseantibody,38kDaBFA-dependentADP-ribosylationsubstrateantibody,aging-associatedgene9proteinantibody,BARS-38antibody,bb02e05antibody,BOS_5957antibody,CDABP0047antibody,g3pdantibody,G3PDHantibody,gapdantibody,glyceraldehyde3-phosphatedehydrogenaseantibody,glyceraldehydephosphatedehydrogenaseantibody,glyceraldhyde3-phosphatedehydrogenaseantibody,glycerladehyde3phosphatedehydrogenaseantibody,KNC-NDS6antibody,Peptidyl-cysteineS-nitrosylaseGAPDHantibody
CrossReactivity	Human
Applications	WB
Immunogen	GAPDHSO3antibodywasraisedinMouseusingasulfonylatedpeptide(KLHcoupled)correspondingtotheoxidationsensitivesitesequencetohumanGAPDHastheimmunogen

SPECIFICATIONS:

Host	Mouse
Clone	4A1
Isotype	IgG1kappa
MethodofPurification	GAPDHSO3antibodywaspurifiedbyammoniumsulfateprecipitation
Form&Buffer	SuppliedinliquidforminHEPESbufferwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol

STORAGE&SAFETY:

Storage	Aliquotandstorefor1yearat-20degC,avoidfreeze/thawcycles

UsageAssayInformation:

UsageRecommendations	WB:1:200-1000

GENERALINFORMATION:

BiologicalSignificance	Glyceraldehyde-3-phosphatedehydrogenase(GAPDH)isacatalyticenzymecommonlyknowntobeinvolvedinglycolysis.Theenzymeexistsasatetramerofidentical37-kDasubunits.GAPDHcatalyzesthereversiblereductionof1,3-bisphosphoglyceratetoglyceraldehyde3-phosphophateinthepresenceofNADPH.Apartfromplayingakeyroleinglycolysis,thisubiquitouslyexpressedenzymealsodisplaysotheractivitiesunrelatedtoitsglycolyticfunction.GAPDHisreportedtobeinvolvedintheprocessesofDNAreplication,DNArepair,nuclearRNAexport,membranefusionandmicrotubulebundling.OtherstudiesalsoprovideevidenceofGAPDHplayinganessentialpartoftheprogramofgeneexpressionobservedinapoptosisandaspartofthecellularphenotypeofage-relatedneurodegenerativediseases.Onrecentstudy,GAPDHhasidentifiedofthemostoxidantsensitivecellproteins.

BiologicalSignificance

Glyceraldehyde-3-phosphatedehydrogenase(GAPDH)isacatalyticenzymecommonlyknowntobeinvolvedinglycolysis.Theenzymeexistsasatetramerofidentical37-kDasubunits.GAPDHcatalyzesthereversiblereductionof1,3-bisphosphoglyceratetoglyceraldehyde3-phosphophateinthepresenceofNADPH.Apartfromplayingakeyroleinglycolysis,thisubiquitouslyexpressedenzymealsodisplaysotheractivitiesunrelatedtoitsglycolyticfunction.GAPDHisreportedtobeinvolvedintheprocessesofDNAreplication,DNArepair,nuclearRNAexport,membranefusionandmicrotubulebundling.OtherstudiesalsoprovideevidenceofGAPDHplayinganessentialpartoftheprogramofgeneexpressionobservedinapoptosisandaspartofthecellularphenotypeofage-relatedneurodegenerativediseases.Onrecentstudy,GAPDHhasidentifiedofthemostoxidantsensitivecellproteins.

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