TGF-beta Phospho Antibody Array 

Transforming growth factor beta (TGF-β) signaling plays an important role in cell proliferation, differentiation, and repair of many organisms. The signaling process begins with a dimeric TGF-β superfamily ligand binding to a Type II receptor, which enlists a Type I receptor (TGFBR1) and phosphorylates its serine residues. The activated TGFBR1 then phosphorylates and activates cytoplasmic molecules Smad2 and Smad3 for the TGF-β pathway or Smad1/5/9 for the bone morphogenetic protein (BMP) pathway. The phosphorylation of Smads leads to formation of a hetero-oligomeric complex with Smad4, which then moves into the nucleus and interacts with transcription promoters/cofactors and regulates gene expression. TGF-β also participates in the regulation of non-Smad pathways including ERK1/2, JNK/SAPK, and p38 MAP kinase pathways.

TGF-β (TGF-beta) Phospho Antibody Array is a high-throughput ELISA based antibody array for qualitative protein phosphorylation profiling. It is suitable for comparing normal samples to treated or diseased samples, and identifying candidate biomarkers.  This array features site-specific and phospho-specific antibodies, allowing researchers to investigate serine/threonine and tyrosine phosphorylation at specific sites.

Key Features

User’s Guide

    Antibody Array User’s Guide

Product Details

 

Additional Reagent Needed:

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