DSPE-PEG-FITC is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and a fluorescein FITC dye. Fluorescein often called FITC is a commonly used fluorescent tracer in biology for staining cells, tissues, biomarkers or nanoparticles. It has peak absorption or excitation at 494 nm and maximum emission at 521 nm. It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing fluorescent dye label/tag. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the biotin group to non-covalently bind to targeting molecules including antibody, aptamer, protein, and peptide.

References: 1. Noninvasive ultrasound molecular imaging of the effect of statins on endothelial inflammatory phenotype in early atherosclerosis. PloS one 8.3 (2013): e58761 Text.

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