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蚂蚁淘在线 / 品牌中心 / MedKoo / MedKoo Biosciences/Indotecan/402502/2g

MedKoo Biosciences/Indotecan/402502/2g

价格
￥157000.00
货号：402502-2g
浏览量：51
品牌：MedKoo
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商品描述
Indotecan,alsoknownasLMP400,isanovelselectiveandpotenttopoisomeraseIinhibitorwithpotentialanticanceractivitity.IndotecaniscurrentlyinPhaseItrials.

MedKooCat#:402502
Name:Indotecan
CAS#:915303-09-2
ChemicalFormula:C26H26N2O7
ExactMass:478.174
MolecularWeight:478.49
ElementalAnalysis:C,65.26;H,5.48;N,5.85;O,23.41


Synonym:LMP400;LMP-400;LMP400;Indotecan.

IUPAC/ChemicalName:2,3-dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4",5":5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione

InChiKey:FMFIFGLHVOZDEL-UHFFFAOYSA-N

InChiCode:InChI=1S/C26H26N2O7/c1-31-19-10-15-18(13-20(19)32-2)26(30)28(5-3-4-27-6-8-33-9-7-27)24-16-11-21-22(35-14-34-21)12-17(16)25(29)23(15)24/h10-13H,3-9,14H2,1-2H3

SMILESCode:O=C1N(CCCN2CCOCC2)C3=C(C(C4=C3C=C(OCO5)C5=C4)=O)C6=C1C=C(OC)C(OC)=C6


TechnicalData

Appearance:
Solidpowder

Purity:
>98%(orrefertotheCertificateofAnalysis)

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO,notinwater

ShelfLife:
>2yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


AdditionalInformation

  
 
 
 


References

1:JosséR,MartinSE,GuhaR,OrmanogluP,PfisterTD,ReaperPM,BarnesCS,JonesJ,CharltonP,PollardJR,MorrisJ,DoroshowJH,PommierY.ATRinhibitorsVE-821andVX-970sensitizecancercellstotopoisomeraseiinhibitorsbydisablingDNAreplicationinitiationandforkelongationresponses.CancerRes.2014Dec1;74(23):6968-79.doi:10.1158/0008-5472.CAN-13-3369.Epub2014Sep30.PubMedPMID:25269479;PubMedCentralPMCID:PMC4252598.

2:BeckDE,AgamaK,MarchandC,CherguiA,PommierY,CushmanM.SynthesisandBIOLOGicalevaluationofnewcarbohydrate-substitutedindenoisoquinolinetopoisomeraseIinhibitorsandimprovedsynthesesoftheexperimentalanticanceragentsindotecan(LMP400)andindimitecan(LMP776).JMedChem.2014Feb27;57(4):1495-512.doi:10.1021/jm401814y.Epub2014Feb11.PubMedPMID:24517248;PubMedCentralPMCID:PMC3983348.

3:PfisterTD,HollingsheadM,KindersRJ,ZhangY,EvrardYA,JiJ,KhinSA,BorgelS,StotlerH,CarterJ,DivelbissR,KummarS,PommierY,ParchmentRE,TomaszewskiJE,DoroshowJH.DevelopmentandvalidationofanimmunoassayforquantificationoftopoisomeraseIinsolidtumortissues.PLoSOne.2012;7(12):e50494.doi:10.1371/journal.pone.0050494.Epub2012Dec28.PubMedPMID:23284638;PubMedCentralPMCID:PMC3532478.

4:CinelliMA,ReddyPV,LvPC,LiangJH,ChenL,AgamaK,PommierY,vanBreemenRB,CushmanM.Identification,synthesis,andbiologicalevaluationofmetabolitesoftheexperimentalcancertreatmentdrugsindotecan(LMP400)andindimitecan(LMP776)andinvestigationofisomericallyhydroxylatedindenoisoquinolineanaloguesastopoisomeraseIpoisons.JMedChem.2012Dec27;55(24):10844-62.doi:10.1021/jm300519w.Epub2012Dec7.PubMedPMID:23215354;PubMedCentralPMCID:PMC3542640.

5:Balaña-FouceR,PradaCF,RequenaJM,CushmanM,PommierY,Ã

苏州蚂蚁淘代理MedKoo在中国的业务。 MedKoo北京代理，MedKoo华东代理，MedKoo华北代理，MedKoo华中代理，MedKoo华南代理,MedKoo全国代理。 MedKoo公司是2009年由Qingqi Chen博士创立。在美国北卡罗来纳州的三角研究园区有运营办公室，其研发和生产车间位于中国。陈博士在加入MedKoo之前，是中山大学药学院（中山大学，中国广州）和中国科学院（北京）“100人计划”的杰出教授。对小分子抗癌药物有浓厚兴趣，发表了100多篇论文，获得20多项。Medkoo是处于先进地位的小分子抗癌试剂，激酶抑制剂和其他相关化学品的优秀供应商。 MedKoo部分产品列表：MedKoo全国代理 406757 10058-F4 530576 10074-G5 600110 10-Deacetylbaccatin III 530429 10-Gingerol 406281 10-Hydroxycamptothecin 341231 10-Hydroxyyohimbine 571387 [11C]-ABP688 526406 11-deoxy-PGF2a 525629 123C4   561223 12-Crown-4 featured 525697 1,3,5,6-Tetrahydroxyxanthone 526087 1,3,5-Trihydroxyxanthone 584120 1,3,7-Trimethyluric acid 527871 1,3-Dicaffeoylquinic acid 530605 1400W HCl