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蚂蚁淘在线 / 品牌中心 / MedKoo / MedKoo Biosciences/GW788388/401488/500mg

MedKoo Biosciences/GW788388/401488/500mg

价格
￥29000.00
货号：401488-500mg
浏览量：114
品牌：MedKoo
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商品描述
GW788388isanewTGF-betatypeIreceptorinhibitorwithamuchimprovedpharmacokineticprofilecomparedwithSB431542.WestudieditseffectinvitroandfoundthatitinhibitedboththeTGF-betatypeIandtypeIIreceptorkinaseactivities,butnotthatoftherelatedbonemorphogenicproteintypeIIreceptor.Further,itblockedTGF-beta-inducedSmadactivationandtargetgeneexpression,whiledecreasingepithelial-mesenchymaltransitionsandfibrogenesis.

MedKooCat#:401488
Name:GW788388
CAS#:452342-67-5
ChemicalFormula:C25H23N5O2
ExactMass:425.18518
MolecularWeight:425.48242
ElementalAnalysis:C,70.57;H,5.54;N,16.46;O,7.52


Synonym:GW788388;GW-788388;GW788388

IUPAC/ChemicalName:4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

InChiKey:SAGZIBJAQGBRQA-UHFFFAOYSA-N

InChiCode:InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)

SMILESCode:O=C(NC1CCOCC1)C2=CC=C(C3=NC=CC(C4=CNN=C4C5=NC=CC=C5)=C3)C=C2


TechnicalData

Appearance:
solidpowder

Purity:
>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:
ViewCoA:currentbatch,Lot#BBC70216

QCData:
ViewQCdata:currentbatch,Lot#BBC70216

SafetyDataSheet(MSDS):
ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO,notinwater

ShelfLife:
>2yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


AdditionalInformation

 
 
 
 


References

1:TanSM,ZhangY,ConnellyKA,GilbertRE,KellyDJ.Targetedinhibitionofactivinreceptor-likekinase5signalingattenuatescardiacdysfunctionfollowingmyocardialinfarction.AmJPhysiolHeartCircPhysiol.2010May;298(5):H1415-25.Epub2010Feb12.PubMedPMID:20154262.

2:LagaresD,García-FernándezRA,JiménezCL,Magán-MarchalN,BusnADIegoO,LamasS,Rodríguez-PascualF.Endothelin1contributestotheeffectoftransforminggrowthfactorbeta1onwoundrepairandskinfibrosis.ArthritisRheum.2010Mar;62(3):878-89.PubMedPMID:20131241.

3:NomaK,SmalleyKS,LioniM,NaomotoY,TanakaN,El-DeiryW,KingAJ,NakagawaH,HerlynM.Theessentialroleoffibroblastsinesophagealsquamouscellcarcinoma-inducedangiogenesis.Gastroenterology.2008Jun;134(7):1981-93.Epub2008Mar4.PubMedPMID:18439605;PubMedCentralPMCID:PMC2562524.

4:PetersenM,ThorikayM,DeckersM,vanDintherM,GrygielkoET,GellibertF,deGouvilleAC,HuetS,tenDijkeP,LapingNJ.OraladmiNISTrationofGW788388,aninhibitorofTGF-betatypeIandIIreceptorkinases,decreasesrenalfibrosis.KidneyInt.2008Mar;73(6):705-15.Epub2007Dec12.PubMedPMID:18075500.

5:FrazierK,ThomasR,ScicchitanoM,MirABIleR,BoyceR,ZimmermanD,GrygielkoE,NoldJ,DeGouvilleAC,HuetS,LapingN,GellibertF.InhibitionofALK5signalinginducesphysealdysplasiainrats.ToxicolPathol.2007Feb;35(2):284-95.PubMedPMID:17366323.

6:GellibertF,deGouvilleAC,WoolvenJ,MathewsN,NguyenVL,Bertho-RuaultC,PatikisA,GrygielkoET,LapingNJ,HuetS.Discoveryof4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide(GW788388):apotent,selective,andorallyactivetransforminggrowthfactor-betatypeIreceptorinhibitor.JMedChem.2006Apr6;49(7):2210-21.PubMedPMID:16570917.

苏州蚂蚁淘代理MedKoo在中国的业务。 MedKoo北京代理，MedKoo华东代理，MedKoo华北代理，MedKoo华中代理，MedKoo华南代理,MedKoo全国代理。 MedKoo公司是2009年由Qingqi Chen博士创立。在美国北卡罗来纳州的三角研究园区有运营办公室，其研发和生产车间位于中国。陈博士在加入MedKoo之前，是中山大学药学院（中山大学，中国广州）和中国科学院（北京）“100人计划”的杰出教授。对小分子抗癌药物有浓厚兴趣，发表了100多篇论文，获得20多项。Medkoo是处于先进地位的小分子抗癌试剂，激酶抑制剂和其他相关化学品的优秀供应商。 MedKoo部分产品列表：MedKoo全国代理 406757 10058-F4 530576 10074-G5 600110 10-Deacetylbaccatin III 530429 10-Gingerol 406281 10-Hydroxycamptothecin 341231 10-Hydroxyyohimbine 571387 [11C]-ABP688 526406 11-deoxy-PGF2a 525629 123C4   561223 12-Crown-4 featured 525697 1,3,5,6-Tetrahydroxyxanthone 526087 1,3,5-Trihydroxyxanthone 584120 1,3,7-Trimethyluric acid 527871 1,3-Dicaffeoylquinic acid 530605 1400W HCl