Description

Gibco®Dynamis™AGT™dryformatmediumisspecificallydesignedtoofferthehighestbatchandfed-batchcultureperformanceandyieldwithrecombinantCHOcellsinachemicallydefinedenvironment.Thechemicallydefined,protein-free,animalorigincomponent-freeformulationprovidesthepowertoachievehightiters,startprocessdevelopmentfaster,andstreamlineorsimplifytransfertomanufacturingscale.

Powertoachievehighertiters
Dynamis™AGT™MediumisfortifiedtohelpmaximizerecombinantCHOcellgrowthandproteinexpressioninsUSPensionbatchculture,offering170%greaterproductionthanselectcompetitivemediawithsimpleglucosesupplementationbyday14.CulturesgrowninDynamis™AGT™MediumextendtoevenhighertitersdemonstratinggoodcellviABIlityouttoday21.Thismediumcanalsoprovideupto60%greaterfed-batchgrowthandproductionoverglucose-onlyfed-batchcultureforselectedcelllinesandapplicationswhenusedwithEfficientFeed™C+AGT™Supplement.

Powertostartprocessdevelopmentfaster
Asafortifiedmedium,Dynamis™AGT™providesthepowertogettoahighcelldensityover10millioncellspermLfasterthancompetitiveproductsandsustainsthatcelldensitylongerbyjustmaintainingglucoselevels.Theviablecellgrowthachievedmakeitagoodchoiceforscale-upifyouhavestartedwithCDFortiCHO™medium.WhenpairedwithEfficientFeed™C+AGT™Supplement,itprovidesafastandefficientwaytodevelopaprocess.

Thepowertostreamlinetransfertomanufacturing
BychoosingDynamis™AGT™Medium,youobtainnotonlythebenefitsofthemediumformulation,butalsothebenefitsofAGT™dryformattechnology.Thisall-in-oneproductisdesignedtosimplifyscale-upandmanufacturingbybeingeasytoreconstitute(justaddwater),withnoadjustmentsofpHorosmolaritynecessary.Thiscanhelpprovideefficienciesthroughsupplychainsimplicity,reconstitutionsimplicity,andthereforehelpreduceexpense.

UseDynamis™AGT™Mediumwhen:
•ThecelllineyouareusingisatransfectedCHOK1,GSCHO,orCHO-S™cellline
•Maximumbatchculturecelldensitiesandproteintitersareneeded
•Youhavetimetoadaptcellsintoanewmediuminanefforttomaximizetiters
•Cellhealthatharvestisapriorityfordownstreamprocessing

WhentoconsideranotherGibco®medium

ConsiderCDOptiCHO™Mediumwhen:
•YouareusingatransfectedCHOcelllineotherthanCHOK1,GSCHO,orCHO-S™celllines
•Optimizationoffeedingstrategieswillbepartofyourbasemediumselectiontestinginanefforttomaximizeproductivity
•YourCHOcelllineishardtogroworadapt

ConsiderCDCHOMediumwhen:
•YourGSCHOcellsarerecommendedtobegrowninCDCHOmedium
•YourcellshavebeensuccessfullyculturedinCDCHOmediuminthepastandyourprocessisnearingaregulatoryfiling(DMFavailable)

ConsiderCDDG44Mediumwhen:
•YouuseparentalDG44orDXB11CHOcells(dhfr-)

Designyourownmediaspecifictoyourneeds
Whetherit’sabench-levelexperimentorlarge-scalebiomanufacturingprocess,weofferspecializedformats,packaging,andqualitylevelsspecifictoyourneeds.WithGibco®cGMPMediaCustomServices,youcanputthemanufacturingpowerandyearsoftechnicalexperienceofourR&DandBioproductionApplicationSpecialiststoworkforyou.

Gibco®isaregisteredtrademarkofThermofisherScientificInc.Dynamis™andCDFortiCHO™aretrademarksofThermoFisherScientificInc.,ActiCHO(TM)isatrademarkofGEHealthcareBiosciencesAB,BalanCD(R)isaregisteredtrademarkofIrvineScientificSalesCo.,Cellvento(R)isaregisteredtrademarkofMerckKGAA,EXCELL(R)isaregisteredtrademarkofSAFC,HyCell(R)isaregisteredtrademarkofGEHealthcareBiosciencesAB,andPowerCHO(TM)isaregisteredtrademarkofLonza.