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SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Titration of the SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 526-551 from the human protein was used as the immunogen for this SHP2 antibody.
Aliquot the SHP2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
