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Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. [UniProt]
The stated application concentrations are suggested starting points.Titration of the CD79b antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 29-159 was used as the immunogen for the CD79b antibody.
Store the CD79b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
