OVERVIEW:

Synonyms	MonoclonalCytokeratin7antibody,Anti-Cytokeratin7antibody,Cytokeratin-7,Cytokeratin-7antibody,KeratinK7antibody,Cytokeratin7,Cytokeratin7,Cytokeratin7antibody
Applications	IHC-F,IHC-P,WB
Immunogen	Cytokeratin7antibodywasraisedinmouseusingCytoskeletalpreparationoftheRT4humanbladdercarcinomacelllineastheimmunogen

SPECIFICATIONS:

Host	Mouse
Clone	CK-7
Isotype	IgG1
Form&Buffer	Suppliedinlyophilizedform

STORAGE&SAFETY:

Storage	Storeat4degCforshorttermstorage.Forlongtermstoragealiquotandstoreat-20degC,avoidrepeatedfreeze/thawcycles.

UsageAssayInformation:

UsageRecommendations	Optimalconditionstobedeterminedbytheenduser

GENERALINFORMATION:

BIOLOGicalSignificance

KeratinK7isfoundtooccurinthecolumnarandglandularepitheliumofthelung,cervix,breast,bileducts,largercollectingductsofthekidneyandinmesothelium,butisabsentfromgastrointestinalepithelium,hepatocytesandmyoepithelium.Severaltypesofadenocarcinomasoftheurinarytractarenegative,whileadenocarcinomasofthemammarygland,ovaryandlungarepositive.IncolorectalcarcinomaearlystagesarereportedtobenegativebutadvancedstagesoftumordevelopmentarepositiveforkeratinK7expression.Inimmunoblottingtheantibodyisreactivewiththe54kDakeratinK7protein(formerlyalsodesignatedcytokeratin7).

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