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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/Tariquidar二盐酸盐/5757/10/10 mg

Tocris/Tariquidar二盐酸盐/5757/10/10 mg

价格
￥3580.00
货号：5757/10
浏览量：127
品牌：Tocris
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商品描述
Description:PotentP-glycoprotein(P-gp)inhibitor
ChemicalName:N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamidedihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentP-glycoprotein(P-gp)inhibitor(IC50=5.1nM).ReversesdrugresistanceinmultipleMDRcelllines.Actsasasubstrateforbreastcancerresistanceprotein(BCRP)atlowconcentrationsandactsasaninhibitorofBCRPwhenusedat>100nMconcentration.Potentiatesthecytotoxiceffectsofdoxorubicin(Cat.No.2252)andmitoxantrone(Cat.No.4250)invitro.

TechnicalData

M.Wt719.66
FormulaC38H38N4O6.2HCl
StorageStoreat-20°C
Purity≥98%(HPLC)
PubChemID121513890
InChIKeyZJCJRGRTDKIFJJ-UHFFFAOYSA-N
SmilesO=C(C1=CC(OC)=C(OC)C=C1NC(C2=CN=C(C=CC=C3)C3=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO71.97100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight719.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.39mL6.95mL13.9mL
5mM0.28mL1.39mL2.78mL
10mM0.14mL0.69mL1.39mL
50mM0.03mL0.14mL0.28mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet