Tocris蚂蚁淘在线

SelectivePPARγantagonist;antidiabeticandantiobesityagent.Attenuatestroglitazone-inducedPPARγtranscriptionalactivity(IC₅₀=140μM)withoutaffectingligand-stimulatedPPARα,PPARβorFXRtranscriptionalactivity.InhibitsPPARγ-dependentADIpocytedifferentiationandgrowthinvitroandinvivo.Improvesinsulinsensitivityindiabeticob/obmiceandincreasesHDLlevelsinratsinvivo.

TechnicalData

M.Wt	358.65
Formula	C₁₁H₁₇ClO₇P₂
Storage	DesiccateatRT
Purity	≥99%(HPLC)
CASNumber	76541-72-5
PubChemID	60910
InChIKey	VQHUQHAPWMNBLP-UHFFFAOYSA-N
Smiles	COP(=O)(OC)OC(C1=CC=C(Cl)C=C1)P(=O)(OC)OC

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	water	35.87	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight358.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.79mL	13.94mL	27.88mL
5mM	0.56mL	2.79mL	5.58mL
10mM	0.28mL	1.39mL	2.79mL
50mM	0.06mL	0.28mL	0.56mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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Tocris/SR 202/2022/50/50 mg

BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets