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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/IOX 2/4451/10/10毫克

Tocris/IOX 2/4451/10/10毫克

价格
￥4180.00
货号：4451/10
浏览量：127
品牌：Tocris
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商品描述
Description:Potent,selectiveHIF-1αprolylhydroxylase-2(PHD2)inhibitor
ChemicalName:N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitorofHIF-1αprolylhydroxylase-2(PHD2)(IC50=21nM).Displaysover100-foldselectivityforPHD2overfactorinhibitingHIF-1(FIH-1)andhistonedemethylasesJMJD2A,JMJD2C,JMJD2EandJMJD3.Cellpermeable.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheIOX2probesummaryontheSGCwebsite.

CompoundLibraries

IOX2isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt352.34
FormulaC19H16N2O5
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber931398-72-0
PubChemID54685215
InChIKeyCAOSCCRYLYQBES-UHFFFAOYSA-N
SmilesOC(C1=CC=CC=C1N2CC3=CC=CC=C3)=C(C(NCC(O)=O)=O)C2=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO35.23100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight352.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.84mL14.19mL28.38mL
5mM0.57mL2.84mL5.68mL
10mM0.28mL1.42mL2.84mL
50mM0.06mL0.28mL0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet