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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/CGK 733/2639/50/50毫克

Tocris/CGK 733/2639/50/50毫克

价格
￥12580.00
货号：2639/50
浏览量：127
品牌：Tocris
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商品描述
Description:Inducesapoptosisinprematurelysenescentcells
ChemicalName:α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

OriginallydefinedasaselectiveinhibitorofATRandATMkinases.Inducescelldeathinprematurelysenescentbreastcancercells.Decreasesp21CIP1levelsinprematuresenescentMCF-7andHCT-116cells;alsoexhibitsantiproliferativeactivityinarangeofcancercelllines.Blockscamptothecin-inducedp53phosphorylationandprotectscellsfromcamptothecin-inducedapoptosis.

CompoundLibraries

CGK733isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt555.84
FormulaC23H18Cl3FN4O3S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber905973-89-9
PubChemID6605258
InChIKeyHLCDNLNLQNYZTK-UHFFFAOYSA-N
Smiles[O-][N+](=O)C1=CC(NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C2=CC=CC=C2)C(Cl)(Cl)Cl)=CC=C1F

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO55.58100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight555.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.8mL9mL17.99mL
5mM0.36mL1.8mL3.6mL
10mM0.18mL0.9mL1.8mL
50mM0.04mL0.18mL0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet