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Biological Activity
Endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo.
Technical Data
| M. Wt | 2197.61 |
| Formula | C93H157N27O28S3 |
| Sequence |
GLSKGCFGLKLDRIGSMSGLGC (Modifications: Disulfide bridge between 6 - 22) |
| Storage | Desiccate at -20°C |
| CAS Number | 127869-51-6 |
| PubChem ID | 16179407 |
| InChI Key | UHSBKBYWHCBDCJ-DYGWFTAGSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2197.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.46 mL | 2.28 mL | 4.55 mL |
| 5 mM | 0.09 mL | 0.46 mL | 0.91 mL |
| 10 mM | 0.05 mL | 0.23 mL | 0.46 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.09 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Suga et al (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130 229 PMID: 1309330
Pejchalova et al (2007) C-natriuretic peptide: An important regulator of cartilage. Mol.Genet.Metab. 92 210 PMID: 17681481
Rose and Giles (2008) Natriuretic peptide C receptor signalling in the heart and vasculature. J.Physiol. 586 353 PMID: 18006579
Keywords: C-type natriuretic peptide (1-22) (human, rat, swine), supplier, Endogenous, peptide, agonists, NPR2, ANP, Receptors, Atrial, Natriuretic, Peptide, Natriuretic, Peptide, Receptor, Natriuretic, Peptide, Receptor, Tocris Bioscience
