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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/Asenapine马来酸盐/3737/10/10 mg

Tocris/Asenapine马来酸盐/3737/10/10 mg

价格
￥3180.00
货号：3737/10
浏览量：127
品牌：Tocris
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商品描述
Description:Novelantipsychoticagent
ChemicalName:(3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolemaleate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Novelpsychopharmacologicagent.DisplaysantagoNISTactivityat5-HT,dopamine,noradrenalinandhistaminereceptorsubtypes(pKivaluesare8.60,8.40,10.15,9.75,10.46,8.84,9.60,9.94,8.85,8.90,8.84,9.38,8.95,8.93,8.9,9.49,8.91,9.00and8.21for5-HT1A,5-HT1B,5-HT2A,5-HT2B,5-HT2C,5-HT5A,5-HT6,5-HT7,D1,D2L,D2S,D3,D4,α1A,α2A,α2B,α2C,H1andH2receptorsrespectively).Displaysnoappreciableaffinityformuscarinicreceptors.Exhibitspotentactivityinanimalmodelspredictiveofantipsychoticefficacy.

CompoundLibraries

AsenapinemaleateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt401.84
FormulaC17H16ClNO.C4H4O4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber85650-56-2
PubChemID73416848
InChIKeyQGBIWSABMNWWNB-FGYPTBLJSA-N
SmilesCN2C[C@]1([H])C3=C(C=CC=C3)OC4=C(C=C(Cl)C=C4)[C@]([H])1C2.CN6C[C@@]5([H])C7=C(C=CC=C7)OC8=C(C=C(Cl)C=C8)[C@@]([H])5C6

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.18100
ethanol20.0950

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight401.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.49mL12.44mL24.89mL
5mM0.5mL2.49mL4.98mL
10mM0.25mL1.24mL2.49mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet