Thebindingof?-arrestinstoagoNIST-occupiedGPCRscoincideswiththerecruitmentofSrcfamilytyrosinekinases,includingc-Src,Hckandc-Fgr(Src-TK),tothereceptor—?-arrestincomplex.Severalsignalingeventshavebeenreportedtoinvolve?-arrestin-dependentSrcrecruitment.Theseincludetheregulationofclathrin-dependent?2-adrenergicreceptorendocytosisbytyrosinephosphorylationofdynamin,Ras-dependentactivationoftheERK1/2MAPkinasecascadeandstimulationofcellproliferationby?2-adrenergicandneurokininNK1receptors,andstimulationofchemokineCXCR1receptor-mediatedneutrophildegranulation

Contributor:KosiGramatikoff,PhD

REFERENCES:AndrewJetal.PhysiologicalRegulationofGProtein-LinkedSignalingPhysiolRev,Oct1999;79:1373-1430.K.Palczewski.StructureandfunctionsofarrestinsProteinSci.,Sep1994;3:1355-1361.KLPierceandRJLefkowitz.Classicalandnewrolesofbeta-arrestinsintheregulationofG-protein-coupledreceptors.NatRevNeurosci,Oct2001;2(10):727-33.MoritzBünemannandM.MarleneHosey.G-proteincoupledreceptorkinasesasmodulatorsofG-proteinsignalingJ.Physiol.,May1999;517:5-23.RobertJ.Lefkowitz.GProtein-coupledReceptors.III.Newrolesforreceptorkinasesand-arrestinsinreceptorsignalinganddesensitization.J.Biol.Chem.,Jul1998;273:18677-18680.

================  蚂蚁淘在线  ================

免责声明：本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容

版权声明：未经蚂蚁淘在线授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的，应该授权范围内使用，并注明“来源：蚂蚁淘在线”。违反上述声明者，本网将追究其相关法律责任。