GeneralInformation

Product

RUNX3AntibodyAffinityPurified

Description

AffinityPurifiedRunt-relatedtranscriptionfactor3AntibodyC-epitope

VerifiedApplications

ELISA,IMM,WB

Host

Rabbit

SpeciesCrossReactivity

Human,Mouse,Rat

Immunogen

Syntheticpeptidetakenwithinaminoacidregion200-250onhumanRunt-relatedtranscriptionfactor3protein.

Accession#

NCBI: NP_001026850.1

PhysicalProperties

Quantity

100µg

Volume

200µl

Concentration

0.52-0.53µg/µlinantibodystabilizationbuffer

Form

AffinityPurified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰Cforlongtermstorage

ApplicationProtocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

WesternBlot

1:500

Protein

Uniprot#

Q13761

Overview

CBFbindstothecoresite,5-PYGPYGGT-3,ofanumberofenhancersandpromoters,includingmurineleukemiavirus,polyomavirusenhancer,T-cellreceptorenhancers,lck,IL-3andGM-CSFpromoters.

MolecularFunction

ATPbinding,RNApolymeraseIIregulatoryregionsequence-specificDNAbinding

SubcellularLocation

Nucleus,cytoplasm

Structure

Heterodimerofanalphaandabetasubunit.ThealphasubunitbindsDNAasamonomerandthroughtheRuntdomain.DNA-bindingisincreasedbyheterodimerization.InteractswithTLE1andSUV39H1.

AlternativeNomenclature

Acutemyeloidleukemia2proteinantibody

AML2antibody

CBFalpha3antibody

CBFA3antibody

Corebindingfactoralpha3subunitantibody

corebindingfactorantibody

Corebindingfactorruntdomainalphasubunit3antibody

Core-bindingfactorsubunitalpha-3antibody

FLJ34510antibody

MGC16070antibody

OncogeneAML2antibody

PEA2alphaCantibody

PEBP2alphaCantibody

Pebp2a3antibody

PEBP2aCantibody

Polyomavirusenhancerbindingprotein2alphaCsubunitantibody

runtdomainalphasubunit3antibody

runtrelatedtranscriptionfactor3antibody

RUNX3antibody

SL33enhancerfactor1alphaCsubunitantibody

SL3/AKVcorebindingfactoralphaCsubunitantibody

TranscriptionfactorAML2antibody