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Name
ML-7 hydrochloride
Short description
Selective MLCK inhibitor
Biological description
Selective myosin light chain kinase (MLCK) inhibitor (K_i = 0.3 µM). Shows reversible ATP- competitive inhibition of Ca²⁺ calmodulin independent/ dependant smooth muscle MLCK. Approx 10-fold more potent inhibitor than ML-9 Shows antiglaucomatous actions.
Biological action
Inhibitor
Purity
>99%
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Chemical name
Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Molecular Weight
452.74
Chemical structure
Molecular Formula
C₁₅H₁₇IN₂O₂S.HCl
CAS Number
110448-33-4
PubChem identifier
9803932
SMILES
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl

Storage instructions
room temperature (desiccate)
Solubility overview
soluble in DMSO (25mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.
Saitoh M et al (1987)J Biol Chem 262(16) : 7796-801.
PubMedID: 3108259
The specificities of protein kinase inhibitors: an update.
Bain J et al (2003)Biochem J 371(Pt 1) : 199-204.
PubMedID: 12534346
Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.
Rosenthal R et al (2005)Exp Eye Res 80(6) : 837-45.
PubMedID: 15939040

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