Product Specification:
| Alternative Name: | CCL2, C-C motif chemokine 2, Monocyte chemoattractant protein 1, Small-inducible cytokine A2 |
| Clone: | E10052 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Full-length recombinant human MCP-1. |
| UniProt ID: | P13500 |
| Species reactivity: | Human |
| Applications: | ELISA, WB |
| Application Notes: | Detects a band of ~9kDa by Western blot. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS containing no preservative. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | MCP-1 is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. |
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