Product Specification:
| Alternative Name: | Leucine-rich repeat kinase 2, RIP7, PARK8, Dardarin |
| Host: | Rabbit |
| Immunogen: | Recombinant human LRRK2 (leucine-rich repeat kinase 2) (aa 1838-2133). |
| UniProt ID: | Q5S007 |
| Species reactivity: | Human |
| Specificity: | The strongest recognized epitope is PDQPRLTIPISQ (aa 1843-1854) as defined by epitope mapping. |
| Applications: | IHC (PS), IP, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 1:500)Immunoprecipitation (1:100)Western Blot (1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A-affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Shipped on Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features. |
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