ProductDescription
Rivaroxabanisanorally-bioavailable,oxazolidinone-basedinhibitor(Ki=0.4nM)offactorXa,thefactorinthebloodcoagulationpathwayleADIngtothrombingenerationandclotformation.[1]Itisapprovedforbothdeepveinthrombosisandpulmonaryembolism.Itis>10000-foldselectiveforfXaoverotherBIOLOGicallyrelevantserineproteases.Rivaroxabaninhibitsprothrombinase-bound(IC50=2.1nM,andclot-associatedfactorXa(IC50=75nM)inadose-dependentmanner.[1]
Invivo,RivaroxabaninhibitsendogenousfXamorepotentlyinhumanandrabbitplasma(IC50=21nM)thaninratplasma(IC50=290nM).[2]Inhumanplasma,PTandaPTTweredoubledat0.23and0.69uM,respectively.
Technicalinformation:
| ChemicalFormula: | C19H18ClN3O5S | |
| CAS#: | 366789-02-8 | |
| MolecularWeight: | 435.88 | |
| Purity: | >99% | |
| Appearance: | White | |
| ChemicalName: | (S)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | Rivaroxaban,Xarelto,BAY-59-7939,BAY59-7939,BAY59-7939 |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Perzbornetal.,Rivaroxaban:aneworalfactorXainhibitor.Arterioscler.Thromb.Vasc.Biol.2010,30,376-381.PubmedID:20139357 |
| 2. | Perzbornetal.,InvitroandinvivostudiesofthenovelantithromboticagentBAY59-7939--anoral,directFactorXainhibitor.J.Thromb.Haemost.2005,3(3),514-521.PubmedID:15748242 |
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