ProductDescription
MitomycinCisaquinone-basedantitumorantibioticthatcrosslinksthecomplementarystrandsoftheDNAdoublehelixwithexquisitebase-andregioselectivityfortheN2ofguanine.(1)Itfirstenteredclinicaltrialsin1958hasbeenemployedsince1974incombinationchemotherapytreatments(2)
MitomycinChasbeenshowntoinduceapoptosisthroughcaspaseprocessing.InMCF-7breastcancercelllines,mitomycinCtreatmentledtoactivecaspase-7,-8,and-9processing,withminimaleffecttocaspase-3.(3)
Morerecently,mitomycinCwasobservedtoactirreversIBLyuponthioredoxinreductase(TrxR)inatime-andconcentration-dependentmanner.InDTNBandinsulinassays,mitomycinCinhibitedTrxRatIC50sof3uMand1uM,respectively.(4)
Technicalinformation:
| ChemicalFormula: | C15H18N4O5 | |
| CAS#: | 50-07-7 | |
| MolecularWeight: | 334.33 | |
| Purity: | >98% | |
| Appearance: | purplesolid | |
| ChemicalName: | [6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2",3":3,4]pyrrolo[1,2-a]indol-8-yl]methylcarbamate | |
| Solubility: | Upto20mMinDMSO | |
| Synonyms: |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Tomasz,M.,MitomycinC:small,fast,anddeadly(butveryselective).Chem.Biol.1995,2,575-579.PubmedID:9383461 |
| 2. | Crookeetal.,MitomycinC:areview.CancerTreatmentRev.1976,3,121-139.PubmedID:786455 |
| 3. | Pirniaetal.,MitomycinCinducesapoptosisandcaspase-8and-9processingthroughacaspase-3andFas-independentpathway.CellDeathDifferentiation,2002,9,905-914.PubmedID:12181741 |
| 4. | Pazetal.,ANewMechanismofActionfortheAnticancerDrugMitomycinC:Mechanism-BasedInhibitionofThioredoxinReductase.Chem.Res.Toxicol.2012,25,1502-1511.PubmedID:786455 |
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