Hh-Ag1.5 is a small-molecule chemical agonist of Smoothened (Smo) receptor and is an activator of sonic hedgehog (Shh) signaling. It is derived from an initial synthetic hit compound "Hh-Ag1.1", and optimized to achieve the activity IC50 = 1 nM for agonist activity.

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Technical information:

Chemical Formula:		C28H26N3OS
CAS #:		612542-14-0
Molecular Weight:		526.04
Purity:		>98%
Appearance:		Yellow solid
Chemical Name:		3-chloro-4,7-difluoro-N-(4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
Solubility:		Up to 50 mM in DMSO

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Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

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Reference:

1.	The Hedgehog Signaling Pathway as a Target for Anticancer Drug Discovery. Borzillo and Lippa. Current Topics in Medicinal Chemistry 2005, (5), 147-157.
2.	Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. Frank-Kamenetsky et. al. Journal of Biology 2002 (1): 10.2-10.19.

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Other Information:

Product Specification (pdf)MSDS (pdf)

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