ProductDescription
SYN115(Tozadenant)isaorally-available,benzothiazole-based,antagoNISToftheAdenosineA2AreceptorforthetreatmentofParkinson"sdiseaseandotherCNS-relatedconditions.SYN115isbeingpursuedasamonotherapyaswellasincombinationwithL-dopamineandisbeingstudiedforitspotentialneuroprotectiveeffects.[1]
AnimalstudieswithSYN115supportbeliefsthatA2AantagonistsreduceParkinson"ssymptomsbyreducingtheinhibitoryoutputofthebasalgangliaindirectpathway.UsingCerebralBloodFlow(CBF)asapharmacodynamicparameter,studieshaveshownthatSYN115inducesasignificantdecreaseinthalamicCBF,consistentwiththedeactivationoftheindirectpathway.[2]
Technicalinformation:
| ChemicalFormula: | C19H26N4O4S | |
| CAS#: | 870070-55-6 | |
| MolecularWeight: | 406.5 | |
| Purity: | >98% | |
| Appearance: | White | |
| ChemicalName: | 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide | |
| Solubility: | Upto50mMinDMSO | |
| Synonyms: | SYN115,SYN-115 |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | BiotieTherapieswebsite(2013-04-24) |
| 2. | Blacketal.,QuantificationofIndirectPathwayInhibitionbytheAdenosineA2aAntagonistSYN115inParkinsonDisease.Blacketal.,J.Neurosci.2010,30(48),16284-16292.PubmedID:21123574 |
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