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蚂蚁淘在线 / 品牌中心 / Cellagen / Cellagentech/MK-0524 (Laropiprant) | Prostaglandin D2/DP antagonist/C6052-5/5 mg (powder)
商品描述
ProductDescription
MK0524,afusedindole-basedantagoNISTofprostaglandinD2(DP),hasaKibindingaffinityof0.57nMandaKddissociationconstantof0.03nM.WiththeexceptionoftheTxA2receptor(Ki=2.95nM),MK0524hasexcellentselectivityoveranumberofotherprostanoidreceptors(EPfamily,FP,andIP).Inafunctionalactivityassayinplatelet-richplasmaandwashedplatelets,MK0524hadanIC50of0.09nM.[1]
MK-0524hasbeenshowntoblocknicotinicacid-inducedcutaneousvasodilationandalsoantagonizesprostaglandinD1(DP1)inamouseDP1functionalassayatanIC50of1.1nM.[2]
Technicalinformation:
| ChemicalFormula: | C21H19ClFNO4S | |
| CAS#: | 571170-77-9 | |
| MolecularWeight: | 435.9 | |
| Purity: >98% | ||
| Appearance: | White | |
| ChemicalName: | [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-aceticacid | |
| Solubility: | Upto50mMinDMSO | |
| Synonyms: | MK-0524,MK-0524A,MK0524,Laropiprant,Cordaptive,Tredaptive |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Sturinoetal.,DiscoveryofaPotentandSelectiveProstaglandinD2ReceptorAntagonist,[(3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-aceticAcid(MK-0524).J.Med.Chem.2007,50,794-806.PubmedID:17300164 |
| 2. | Chengetal.,AntagonismoftheprostaglandinD2receptor1suppressesnicotinicacid-inducedvasodilationinmiceandhumans.Proc.Natl.Acad.Sci.2006,103(17),6682-6687.PubmedID:16617107 |
Cellagen的FlexiWash FW400自动膜/凝胶洗涤站设计用于自动Western blot膜洗涤和孵育过程。将蛋白质转移到膜上后，将膜加载到FlexiWash上以进行自动封闭，孵育和洗涤循环。用户只需要准备所需的试剂，启动印迹程序，然后让FW400进行其余操作即可。凭借独特的液体处理设计，FW400同时支持四个清洗/孵育过程，每个过程均可独立编程，并针对特定应用实现全自动。FW400也可用于蛋白质或DNA凝胶染色和脱色，或涉及重复液体处理和孵育周期的任何其他应用。
