The cell permeable DMNPE-caged Luciferin is as a bioluminescent luciferase substrate used to measure intracellular functions since it readily crosses cell membranes. It is a D-luciferin ester analogue of luciferin.Once the caged luciferin is inside the cells, active luciferin can be released by the action of endogenous intracellular esterases or by a flash of UV light.

This implies:

1. A more efficient delivery of luciferin into intact living cells & improved sensitivity analysis of in vivo luciferase assays
2. A long-term measurement of luciferase activity since hydrolysis by esterases allows a continuous supply of active Luciferin

 

DMNPE-caged luciferin appears a good alternative to D-Luciferin classically used to measure luciferase activity in live cells. Indeed, the difficulty to deliver D-Luciferin into living cells renders in vivo quantification limited to a certain extent - for example, permeability issues at neutral pH.

Storage: -20°C and protect from light

Shipping Conditions: Room temperature

DMNPE-caged luciferin is provided in an amber bottle under nitrogen. 

 

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自2003年以来，OZ Biosciences为全球科学界和制药行业创建，开发和生产专门用于转染和转导工具的创新分子递送系统。OZ Biosciences专注于体外和体内应用的生物分子（例如DNA，RNA和蛋白质）的输送技术。在过去的几年中，生命科学经历了技术革命。在基因组学，功能基因组学和蛋白质组学领域所取得的进展为更好地理解基本生物学过程和开发下一代药物创造了绝佳的机会。