品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
BIOLOGICAL INFORMATION
DescriptionDuring apoptosis, activated caspase-3 cleaves several substrates, including poly(ADP-ribose) polymerase, which it specifically targets at the amino sequence DEVD. Ac-DEVD-pNA is a para-nitro aniline chromophore cleaved by caspases (Km = 18, 11, 32, 180, and 12 µM for caspases-1, -3, -4, -6, and -7, respectively). It is not cleaved by caspase-2.2 Cleavage is monitored colorimetrically at 405 nm.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10922
CAS No.189950-66-1
NameAc-DEVD-pNA
Chemical NameAc-DEVD-pNA
Purity≥98%
SynonymsN/A
FormulaC26H34N6O13
Molecular Weight638.58
One Letter CodeAc-DEVD-pNA
Three Letter CodeAc-Asp-Glu-Val-Asp-PNA
SMILESCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C
InChI KeyGGXRLUDNGFFUKI-UHFFFAOYSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingBlue Ice
Stability≥ 2 years
REFERENCES & CITATIONS
1.Lazebnik, Y.A.,Kaufmann, S.H.,Desnoyers, S., et al. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347 (1994).
2.Talanian, R.V.,Quinlan, C.,Trautz, S., et al. Substrate specificities of caspase family proteases. The Journal of Biological Chemisty 272(15), 9677-9682 (1997).
3.Nicholson, D.W., et al. 1999. Nature 376: 37-43. PMID: 7596430
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
