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商品描述
BIOLOGICAL INFORMATION
DescriptionEptifibatide is a cyclic heptapeptide containing six amino acids and one mercaptopropionyl (des-amino cysteinyl) residue. An interchain disulfide bridge is formed between the cysteine amide and the mercaptopropionyl moieties. Chemically it is N6 -(aminoiminomethyl)-N2 -(3-mercapto-1-oxopropyl-L- lysylglycyl-L-a-aspartyl- L-tryptophyl-L -prolyl-L-cysteinamide, cyclic (1Ø6)-disulfide. Eptifibatide binds to the platelet receptor glycoprotein (GP) IIb/IIIa of human platelets and inhibits platelet aggregation.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10606
CAS No.188627-80-7
NameEptifibatide
Chemical NameEptifibatide
Purity≥98%
Synonyms Integrilin; Integrelin
FormulaC35H49N11O9S2
Molecular Weight831.96
One Letter CodeN/A
Three Letter CodeMPA-HAR-GLY-ASP-TRP-PRO-CYS-NH2
SMILESC1CC2C(=O)NC(CSSCCC(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N2C1)CC3=CNC4=CC=CC=C43)CC(=O)O)CCCCN=C(N)N)C(=O)N
InChI KeyCZKPOZZJODAYPZ-BONDPLATSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingIce Pack
Stability≥ 2 years
REFERENCES & CITATIONS
1.Zhou, X.,Wu, X.,Sun, H., et al. Efficacy and safety of eptifibatide versus tirofiban in acute coronary syndrome patients: A systematic review and meta-analysis. J. Evid. Based Med. 10(2), 136-144 (2017)
2.Ciborowski, M., and Tomasiak, M. The in vitro effect of eptifibatide, a glycoprotein IIb/IIIa antagonist, on various responses of porcine blood platelets. Acta Pol. Pharm. 66(3), 235-242 (2009)
3.Moser, M.,Bertram, U.,Peter, K., et al. Abciximab, eptifibatide, and tirofiban exhibit dose-dependent potencies to dissolve platelet aggregates. J. Cardiovasc. Pharmacol. 41(4), 586-592 (2003)
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
