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商品描述
BIOLOGICAL INFORMATION
DescriptionCortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin 14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistatin-14 would impair retention, saline or cortistatin 14 was injected intracerebroventricularly after footshock avoidance training into each of a group of CD-1 mice. After one week, training was resumed to determine the effect of cortistatin 14 on retention. Cortistatin 14 was found to impair retention relative to the control group at doses of 0.5-5.0 micrograms.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10134
CAS No.186901-48-4
NameCortistatin 14, human, rat
Chemical NameCortistatin-14,-human,-rat
Purity≥98%
SynonymsCST-14
FormulaC81H113N19O19S2
Molecular Weight1721.01
One Letter CodePCKNFFWKTFSSCK
Three Letter CodePRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS
SMILESCC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)C6CCCN6)C(=O)NC(CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O
InChI KeyDDRPLNQJNRBRNY-WYYADCIBSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingBlue Ice
Stability≥ 2 years
REFERENCES & CITATIONS
1.Aourz N, Portelli J, Coppens J, et al. Cortistatin-14 Mediates its Anticonvulsant Effects Via sst2 and sst3 but Not Ghrelin Receptors. CNS Neurosci Ther. 2014 Mar 31. [Epub ahead of print]. PMID: 24685142.
2.Markovics A, Szoke É, Sándor K, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. PMID: 21695504.
3.Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab. 2002 Aug;87(8):3783-90. PMID: 12161511.
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
