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蚂蚁淘在线 / 品牌中心 / Bio-Synthesis / Bio-Synthesis/[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27)/1 mg/10069-01
商品描述
[NMeG24, NMeI26] Human Islet Amyloid Polypeptide(IAPP) (22 - 27)
Sequence (1LC):
NF-(NMe-G)-A-(NMe-I)-L
Sequence (3LC):
H - Asn - Phe - (NMe - Gly) - Ala - (NMe - Ile) - Leu - OH
Catalog :
10069-01
Unit:
1 mg
Price/Unit:
$215(For other quantities please Contact Us or call 972-420-8505)
Purity:
>95%
Format:
Lyophilized solid, trifluoroacetate (TFA) salt format
Description:
This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.
Storage:
-20°C
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
661.8
Reference/Citations:
- Yan, L. et al. PNAS 103, 2046 (2006),
- Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002),
- Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).
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