Dorsomorphin is a cell permeable pyrrazolopyrimidine compound that act as potent inhibitor of AMP-activated protein kinase (AMPK) (Ki=109nM) and bone morphogenic protein (BMP) signaling (1,2). Dorsomorphin inhibits BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation (3). It has also no effect on components of the ZAPK, Syk, PKCq, PKA, or JAK3. It is shown that dorsomorphin promotes hESC self-renewal by antagonizing autocrine BMP signaling (4).

CAS Number

866405-64-3

Chemical Formula

C₂₄H₂₅N₅O

Chemical Name

6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride

Molecular Weight

399.5

QC Specifications

MASS Spec

Mouse ESC culture for toxicity

Shipping Information

on blue ice

Storage

-20°C protected from light

Stability

Stable for up to 6 months from date of receipt when stored as directed.

Reference

1. Gao et al. (2008) Biol Pharm Bull. 31: 1716–1722.

2. Anderson et al. (2008) Nat. Chem Biol. 4: 15–16.

3. Yu et al. (2008) Nat. Chem Biol. 4: 33–41

4. Gonzalez R et al.(2011) Angew Chem Int Ed Engl. 4;50(15):3439-41