PS48 is an allosteric small molecule that activates phosphoinositide-dependent protein kinase 1 (PDK1) by binding exclusively to the HM/PIF binding pocket rather than the ATP-binding site (1,2). PS48 metabolically facilitates a conversion from mitochondrial oxidation to glycolysis during the reprogramming process. PS48 enhances reprogramming efficiency by about 15-fold (3).

CAS Number

1118807-13-8

Chemical Formula

C17H15ClO2

Chemical Name

5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

Molecular Weight

286.75

QC Specifications

MASS Spec

Mouse ESC culture for toxicity

Shipping Information

on blue ice

Storage

4°C protected from light

Stability

Stable for up to 6 months from date of receipt when stored as directed.

Reference

1. Hindie et al (2009) Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol. 5 758.

2. Stroba et al (2009) 3,5-diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J.Med.Chem. 52 4683.

3. Williams (2010) Elastic network model of allosteric regulation in protein kinase PDK1. BMC Struct.Biol. 10 11