Biomol/2-花生四烯醇甘油-d5/500µg/Cay362162-500

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¥10400.00
货号:Cay362162-500
浏览量:90
品牌:Biomol
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商品描述
Product information "2-Arachidonoyl Glycerol-d5"
2-Arachidonoyl glycerol-d5 (2-AG-d5) contains five deuterium atoms at the 1, 1, 2, 3, and 3 positions of the glycerol moiety. It is intended for use as an internal standard for the quantification of 2-AG by GC- or LC-mass spectrometry. 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the CB1 receptor. Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system, it is the most abundant molecular species of monoacylglycerol found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of PLC and DAG lipase. 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase, with MAG lipase likely being the principle metabolizing enzyme in vivo.
Keywords: 2-AG-d5, 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glycerol-1,1,2,3,3-d5 ester
Supplier: Cayman Chemical
Supplier-Nr: 362162-50

Properties

Application: Standard
MW: 383.6 D
Formula: C23H33D5O4
Purity: >99% deuterated forms (d1-d5)
Format: Solution

Database Information

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H302, H312, H319, H332
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P337+P313, P361+P364, P370+P378, P403+P235, P501
Caution Our products are for laboratory research use only: Not for administration to humans!
Biomol生物样本近年来,研究人员在所有自然科学领域,尤其是生命科学领域取得了可观的科学突破和技术进步。尽管人们在努力模仿和重建生物系统,但是直接来源于活生物体的产品在研究中仍然是不可替代的。永生化的细胞系,细菌和酵母菌株是现代分子生物学和医学研究的基础。诸如裂解物,血液衍生产物,核酸以及组织样品等生物标本在各种实验和临床测试中均作为对照和研究对象。