| (±)-Salsolinol (hydrochloride)depolarize dopamineric neurons |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.
(±)-Salsolinol (hydrochloride) Dilution Calculator
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| Cas No. | 79923-51-6 | SDF | Download SDF |
| Chemical Name | 1,2,3,4-tetrahydro-1-methyl-6,7-isoquinolinediol, monohydrochloride | ||
| Canonical SMILES | CC1NCCC2=C1C=C(O)C(O)=C2.Cl | ||
| Formula | C10H13NO2 • HCl | M.Wt | 215.7 |
| Solubility | Soluble in ethanol;Soluble in DMSO;Soluble in H2O | Storage | Store at 4°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
(±)-Salsolinol targets depolarize dopamineric neurons.
Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions. Progressive loss of dopaminergic neurons is considered as the cause of many motor symptoms associated with Parkinson’s disease.
In vitro: A previous study found that (±)-salsolinol could activate the μ-opioid receptor by the classical G protein-adenylate cyclase pathway. The agonist action of (±)-salsolinol was blocked by the μ-opioid antagonist. The EC50 for the purified stereoisomers (R)- salsolinol and (S)-salsolinol were 6 × 10-4 M and 9 × 10-6 M, respectively. It was found that (±)-salsolinol did not promote the recruitment of β-arrestin. Molecular docking studies showed that the interaction of (R)- and (S)-salsolinol with the μ-opioid receptor was similar to that predicted for the agonist morphine [1].
In vivo: Male Wistar rats were subjected to continuous i.p. dosing of salsolinol at 200 mg/kg for 2 or 4 weeks with either high-fat or normal diet. Results showed that salsolinol could reduce total body mass significantly with no differences in total food intake. In addition, the epididymal fat pad weight over final body mass ratio was lower in salsolinol treated rats with high fat diet. Moreover, the perimeter, e area, as well as short and long axis of the fad pad adipocytes decreased in salsolinol treated animals significantly [2].
Clinical trial: So far, no clinical study has been conducted.
References:[1] Berríos-Cárcamo P, Quintanilla ME, Herrera-Marschitz M, Vasiliou V, Zapata-Torres G, Rivera-Meza M. Racemic Salsolinol and its Enantiomers Act as Agonists of the μ-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway. Front Behav Neurosci. 2017 Jan 23;10:253. doi: 10.3389/fnbeh.2016.00253. eCollection 2016.[2] Aleksandrovych V, Kurnik M, Biaas M, Bugajski A, Thor P, Gil K. The effect of peripheral chronic salsolinol administration on fat pad adipocytes morphological parameters. Folia Med Cracov. 2016;56(1):81-95.
