| AS 101Immunomodulator |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
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- Purity = 98.00%
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Chemical structure
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| Cas No. | 106566-58-9 | SDF | Download SDF |
| Chemical Name | Ammonium trichloro[1,2-ethanediolato-O,O"]-tellurate | ||
| Canonical SMILES | C1CO[Te](O1)(Cl)(Cl)Cl.[NH4+] | ||
| Formula | C2H4Cl3O2Te.NH4 | M.Wt | 312.05 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| Physical Appearance | White crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Ammonium tri-chloro(dioxoethylene-O,O′-)tellurate (AS-101), an anti–IL-10 compound, is a nontoxic immunomodulator.
AS101 (0.5-2.5 μg/ml) decreased IL-10 production in a dose-dependent manner. Incubation of RMCL and RMC in the presence of AS101 gradually and significantly decreased mesangial cell proliferation [1]. AS101 (0.5 μg/ml, 1 μg/ml) decreased tyrosine phosphorylation and nuclear translocation of stat3 via inhibition of IL-10 [2]. AS-101 induced proliferation and IL-2 production by human lymphocytes and enhanced the production of IL-2 and colony-stimulating factor by mouse spleen cells. Systemically administration of AS-101 to mice mediated antitumour effects. AS-101 directly enhanced the ratio of OKT4 to OKT8-positive cells in cultured mononuclear cells from AIDS patients [3]. AS101 showed significant bone marrow (BM)-sparing effects and preventd hair loss in chemotherapy-treated patients, with minimal overall toxicity [4]. In mice subjected to cecal ligation and puncture (CLP), treatment with AS101 significantly increased survival of septic mice. AS101 treatment restored the ability of these cells to secrete TNF-α and IL-1β. AS101 increased class II Ag expression on peritoneal macrophages. AS101 increased the level of IFN-γ secreted by splenocytes [5].
References:[1] Kalechman Y, Sredni B, Weinstein T, et al. Production of the novel mesangial autocrine growth factors GDNF and IL-10 is regulated by the immunomodulator AS101[J]. Journal of the American Society of Nephrology, 2003, 14(3): 620-630.[2] Kalechman Y, Gafter U, Weinstein T, et al. Inhibition of Interleukin-10 by the Immunomodulator AS101 Reduces Mesangial Cell Proliferation in Experimental Mesangioproliferative Glomerulonephritis ASSOCIATION WITH DEPHOSPHORYLATION OF STAT3[J]. Journal of Biological Chemistry, 2004, 279(23): 24724-24732.[3] Sredni B, Caspi R R, Klein A, et al. A new immunomodulating compound (AS-101) with potential therapeutic application[J]. Nature, 1987, 330(6144): 173-176.[4] Sredni B, Albeck M, Tichler T, et al. Bone marrow-sparing and prevention of alopecia by AS101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[J]. Journal of Clinical Oncology, 1995, 13(9): 2342-2353.[5] Kalechman Y, Gafter U, Gal R, et al. Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[J]. The Journal of Immunology, 2002, 169(1): 384-392.
