| BardoxoloneOnce-a-day treatment for CKD |
Sample solution is provided at 25 µL, 10mM.
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- Purity = 99.34%
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Chemical structure
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| Cas No. | 218600-44-3 | SDF | Download SDF |
| Synonyms | CDDO;RTA 401;RTA401;RTA-401 | ||
| Chemical Name | (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid | ||
| Canonical SMILES | CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)O)C | ||
| Formula | C31H41NO4 | M.Wt | 491.66 |
| Solubility | ≥49.2 mg/mL in DMSO, ≥2.682 mg/mL in EtOH with ultrasonic and warming, <2.31 mg/ml="" in="" h2o=""> | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata"s portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2, an important biological target that controls the production of many of the body"s antioxidant and detoxification enzymes. Because oxidative stress and inflammation occur throughout the course of chronic kidney disease (CKD) and are known to contribute to loss of kidney function, agents that activate the Nrf2 pathway in patients with CKD may provide a novel method for preserving or improving kidney function. Bardoxolone methyl is currently being investigated as a potential oral once-a-day treatment for CKD.
