- Efinaconazole
- Isavuconazole
| Tizoxanideanti-infective compound |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
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- Purity = 98.40%
- COA (Certificate Of Analysis)
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- NMR (Nuclear Magnetic Resonance)
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Chemical structure
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| Cas No. | 173903-47-4 | SDF | Download SDF |
| Chemical Name | 2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide | ||
| Canonical SMILES | OC1=C(C=CC=C1)C(NC2=NC=C(S2)[N+]([O-])=O)=O | ||
| Formula | C10H7N3O4S | M.Wt | 265.25 |
| Solubility | ≥26.5mg/mL in DMSO with gentle warming | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
IC50: 0.17 to 0.21 μM for CIVs
Tizoxanide is the active metabolite of nitazoxanide that is a thiazolide anti-infective drug against anaerobic bacteria, protozoa, and a range of viruses.
Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are major public health problems, causing more than an estimated 500 million chronic infections worldwide. Both HBV and HCV are a source of liver disease, and are the major risk factors for hepatocellular carcinoma.
In vitro: Previous study found that tizoxanide showed potent inhibition of both HBV and HCV replication. Tizoxanide also exhibited selective inhibition of intracellular HBV replication and extracellular virus production by 2.2.15 cells. Tizoxanide could selectively reduce intracellular HCV replication in AVA5 cells. Moreover, the combination of tizoxanide with either recombinant human interferon alpha 2b (IFNα), or an NS5B (HCV polymerase) inhibitor, 2′-C-methyl cytidine, resulted in synergistic interactions against HCV replication. In addition, antiviral activities of tizoxanide against a full-length genotype 1a replicon were equivalent to that observed for AVA5 cells [1].
In vivo: Animal study in an immunosuppressed rat model suggested that relapses were less frequent after treatment with nitazoxanide, the parent drug of tizoxanide, than with the non-absorbable sinefungin and paromomycin [2].
Clinical trial: Nitazoxanide, the parent drug of tizoxanide, is currently in phase II clinical development for treating chronic hepatitis C [1].
References:[1] Korba BE,Montero AB,Farrar K,Gaye K,Mukerjee S,Ayers MS,Rossignol JF. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res.2008 Jan;77(1):56-63. [2] Gargala G,Delaunay A,Li X,Brasseur P,Favennec L,Ballet JJ. Efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against Cryptosporidium parvum development in sporozoite-infected HCT-8 enterocytic cells. J Antimicrob Chemother.2000 Jul;46(1):57-60.
