| Arginase inhibitor 1Human arginases I and II inhibitor |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
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- View current batch:
- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
| Cell experiment [1]: | |
Cell lines | CHO cells over-expressing human arginase I |
Preparation method | This compound is soluble in DMSO. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
Reacting condition | 0.1, 0.3, 1, 3, 10, 30, 100, and 300 μM; 24 h |
Applications | In CHO cells over-expressing human arginase I, Arginase inhibitor 1 inhibited human arginase I with IC50 value of 8 μM. |
| Animal experiment [1]: | |
Animal models | MI/RI rat model |
Dosage form | 100 mg/kg, i.v.; administered as a bolus 15 min before occlusion of the coronary artery |
Application | In MI/RI rat model, Arginase inhibitor 1 (100 mg/kg, i.v.) reduced infarct size to 35.2% of area at risk (AAR), similar to the intermittent preconditioning (IPC) group. |
Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
References: [1] Wang L, Yu Y, Chow DC et al.Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10;28(2):240-52. | |
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| Cas No. | 1345808-25-4 | SDF | Download SDF |
| Chemical Name | (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid | ||
| Canonical SMILES | N[C@](CCN1CCCCC1)(C(O)=O)CCCCB(O)O | ||
| Formula | C13H27BN2O4 | M.Wt | 286.18 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
