| 13Z,16Z-Docosadienoic AcidFFAR4(GPR120) agonist |
Sample solution is provided at 25 µL, 10mM.
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- Purity = 98.00%
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Chemical structure
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| Cas No. | 17735-98-7 | SDF | Download SDF |
| Synonyms | cis-13,16-Docosadienoic Acid | ||
| Chemical Name | 13Z,16Z-docosadienoic acid | ||
| Canonical SMILES | CCCCC/C=CC/C=CCCCCCCCCCCCC(O)=O | ||
| Formula | C22H40O2 | M.Wt | 336.6 |
| Solubility | ≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A solution in ethanol | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA) formed through a 2-carbon chain elongation of arachi donic acid. 13Z,16Z-Docosadienoic acid acts as an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) [1].
Free fatty acids act as a source of energy and also function as signaling molecules which involved in regulating energy homeostasis. The endogenous ligands for FFAR4 are ω3-FAs, such as α-LA,DHA and EPA. FFAR4 has been involved in diverse physiological process such as anti-inflammation, insulin sensitization, release of gut peptides and alternation of food preference [2].
13Z,16Z-Docosadienoic acid strongly inhibited the secretion of ghrelin by isolated mouse gastric cells [1]. Dietary n-3 polyunsaturated fatty acids (PUFA) ameliorate several human diseases such as coronary heart disease, autoimmune and inflammatory disorders, diabetes, obesity and cancer [3]. This 20:2 PUFA has already been identified in fish, mammals, plants, and anaerobic fungi.
References:[1]. X. Lu, X. Zhao, J. Feng, et al. Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice. Am. J. Physiol. Gastrointest. Liver Physiol. 303(3), G367-376 (2012). [2]. Kimura I. Omega-3 fatty acids and FFAR4[J]. Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors, 2016: 29.[3]. Ma D W L, Seo J, Switzer K C, et al. n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research[J]. The Journal of nutritional biochemistry, 2004, 15(11): 700-706.
