Product Specification:
| Alternative Name: | CYP1A2 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the internal domain (aa 284-298) of human CYP1A2. |
| UniProt ID: | P05177 |
| Species reactivity: | Human |
| Specificity: | Recognizes human CYP1A1. Not suitable for use on rat tissue. |
| Applications: | IHC (FS), IHC (PS), WB |
| Blocking Peptide: | For Blocking peptide see Prod. No. BML-CP0123. |
| Formulation: | Liquid. Serum containing 0.01% sodium azide. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Members of the cytochrome P-450 1A (CYP1A) sub-family are induced by a range of polycyclic aromatic compounds such as benzpyrene, 3-methylcholanthrene (Prod. No. BML-GR239), and pro-carcinogenic heterocyclic aromatic amines. Cigarette smoking has been reported to induce CYP1A2 in human liver, and appears to be a major catalyst in the hepatic activation of PhIP, (2-amino-1-methyl-6-phenylimidazo[4,5,b]-pyridine). The mono-oxygenase inhibitor inhibitor enoxacin induces CYP1A2 in rat liver, whereas a related compound ciprofloxacin does not. |
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