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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Description
HRH4(HistaminereceptorH4)isaubiquitousmessengermoleculereleasedfrommastcells,enterochromaffin-likecells,andneurons.Itsvariousactionsaremediatedbyafamilyofhistaminereceptors,whichareasubsetoftheG-proteincoupledreceptorsuperfamily.Thisgeneencodesahistaminereceptorthatispredominantlyexpressedinhaematopoieticcells.HRH4isthoughttoplayaroleininflammationandallergyreponses,andcontrolsneutrophilreleasefrombonemarrow.Italsoplaysaroleindeterminingeosinophilshapechangeaswellasmastcellchemotaxisandcalciummobilization.LossofHRH4ingastriccarcinomasthroughdeletionisalsothoughttoplayaroleincancergrowth.J.Pharmacol.Exp.Ther.2003.305(3):1212–21.doi:10.1124/jpet.102.046581.PMID12626656;PLoSOne.2012;7(2):e31207,PMID:22363581
Target
HumanHRH4/HistamineH4Receptor
SeeAllHRH4/HistamineH4ReceptorAntibodies
Host
Rabbit
Reactivity
Human(testedor100%immunogensequenceidentity)
Predicted
Monkey(atleast90%immunogensequenceidentity)
Clonality
Polyclonal
Conjugations
Unconjugated.AlsoavailableconjugatedwithAP,APC,Biotin,FITC,HRP,PE.
Purification
Immunoaffinitypurified
Modifications
Unmodified
Applications
- IHC
- IHC-Paraffin(14µg/ml)
- Applicationstestedforthebaseformofthisproductonly
 | PerformingIHC?SeeourcompletelineofImmunohistochemistryReagentsincludingantigenretrievalsolutions,blockingagentsABCDetectionKitsandpolymers,biotinylatedsecondaryantibodies,substratesandmore. |
Immunogen
Synthetic21aminoacidpeptidefrom3rdcytoplasmicdomainofhumanHRH4/HistamineH4Receptor.PercentidentitywithotherspeciesbyBLASTanalysis:Human,Gibbon(100%);Marmoset(90%);Monkey(81%).
BlockingPeptide
LS-E29195-Liquid-50µg-$145.00ImmunizingpeptideusedtogenerateLS-A6816.Usefulforpre-absorptionandneutralizationoftheantibody'santigenbindingsite.
Epitope
CytoplasmicDomain
Specificity
HumanHRH4/HistamineH4Receptor.BLASTanalysisofthepeptideimmunogenshowednohomologywithotherhumanproteins.
Presentation
PBS,0.1%SodiumAzide
Storage
Aliquotandstoreundilutedat-20°Corbelowforupto1year.Canbestoredundilutedat4°Cforupto1month.Avoidfreeze-thawcycles.
Restrictions
Forresearchuseonly.
Guarantee
ThisantibodycarriestheLSBIo100%Guarantee.
LSBioGuaranteeAboutHRH4/HistamineH4Receptor
Q9H3N8AY136745NP_067637.2
LifeSpan是分子病理学领域的行业领导者。LifeSpan销售抗体，免疫组化服务和定位数据库。LifeSpan成立于1995年，已经开发出针对主要类别药物靶标的专有抗体，以研究这些蛋白质在正常和患病人体组织中的表达。 LifeSpan还是高通量成像和癌症识别软件的领导者，并且正在开发用于临床前毒理学和癌症诊断中病理解释的仪器和软件。LifeSpan的客户包括美国，欧洲和日本的100多家制药公司。 产品和服务包括抗体，经过IHC验证的定制抗体合成，IHC合同研究服务，用于合同研究的定制组织微阵列（TMA）构建，病理学和影像学服务，单克隆抗体交叉反应筛选服务，全面人选的订购组织IHC对400多个药物靶标的定位概况，这是一个针对3200个基因的表达集中信息学资源。
